Patel DM, et al. - In the International Childhood Cancer Cohort Consortium, researchers prospectively assessed the risk of childhood leukemia and central nervous system (CNS) tumors in relation to parental occupational exposures. Overall data from 329,658 participants were analyzed using birth cohorts in five countries (Australia, Denmark, Israel, Norway, and the UK). Increased risk of childhood acute myeloid leukemia (AML), but not acute lymphoblastic leukemia (ALL) or CNS tumors, was observed in relation to paternal exposures to pesticides and animals. A positive relation to AML, inverse link with ALL, and no relation to CNS tumors was associated with paternal exposure to organic dust. Paternal agricultural exposures were identified as childhood AML risk factors in this first prospective analysis of pooled birth cohorts and parental occupational exposures.