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Parathyroidectomy influences coronary artery calcium score in asymptomatic hemodialysis patients with secondary hyperparathyroidism

American Journal of Nephrology Dec 05, 2019

Ma Q, et al. - Among asymptomatic patients, researchers used computed tomography to assess the influence of parathyroidectomy (PTX) on coronary artery calcification score (CACS). This investigation was conducted with institutional review board approval. Forty-eight individuals (mean age ± SD 54.50 ± 13.14 years; range 33–77 years) undergoing maintenance hemodialysis who had PTX and 56 individuals (mean age 55.28 ± 12.32 years; range 35–76 years) who did not undergo PTX received prospective follow-up for 2 years. Data reported that the mean square root of CACS did not rise from 23.16 ± 18.58 to 23.68 ± 18.16 from baseline to follow-up for patients who had PTX. Mean square root of CACS rose from 20.21 ± 16.47 to 28.72 ± 20.95 from baseline to follow-up in patients who did not undergo PTX. Calcium and phosphate metabolism dysregulation caused by SHPT can lead to significant progression of CAC in patients with asymptomatic hemodialysis. Low PTH state after PTX can stabilize the progression of CAC in patients with hemodialysis.
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