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Parathyroidectomy for patients with primary hyperparathyroidism and associations with hypertension

JAMA Oct 17, 2019

Graff-Baker AN, et al. - Researchers examined mean arterial pressure and antihypertensive medication use among patients with hypertension undergoing parathyroidectomy for primary hyperparathyroidism vs those without surgery. In this cohort study and retrospective database review of 2,380 participants (79.0% female), patients undergoing parathyroidectomy (n = 501) vs nonsurgical patients (n = 1,879) were younger (mean [SD] age, 65.3 [9.7] vs 71.9 [10.4] years) and were taking fewer antihypertensive medications at baseline (mean [SD] number of medications, 1.2 [1.1] vs 1.5 [1.3]). Patients with parathyroidectomy reported significantly lower median mean arterial pressure after surgery and were significantly less likely to increase antihypertensive medications at 6 months, 1 year, and 2 years after surgery. Outcomes thereby suggest the possible cardiovascular benefits of parathyroidectomy in those with primary hyperparathyroidism and hypertension.
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