Bongers PJ, et al. - Researchers examined the prognostic value of the proportion of tall cells in papillary thyroid carcinoma (PTC). They reviewed patients with PTC and tall cells (defined as having a height-to-width ratio of ≥ 3:1) seen at a high-volume center. Classification of specimens was done as follows: (1) focal tall cell change, containing < 30% of tall cells; (2) tall cell variant, ≥ 30% of tall cells; and (3) control cases selected from infiltrative classical PTCs with no adverse cytologic features. The analysis revealed focal tall cell change in 96 PTCs, the tall cell variant in 35, and 104 as control cases. Outcomes revealed worse prognosis for PTCs with ≥ 10% tall cell change vs those without tall cells. Data thereby emphasize considering PTCs with focal tall cell change outside of the low-risk classification in thyroid cancer management guidelines.