Spasić S, Ordobazari A, Nadji M, et al. - Histologically, thin or broad papillae lined by epithelium showing the features of high-grade squamous intraepithelial lesion characterize papillary squamous cell carcinoma, a rare variant of squamous cell carcinoma. As these neoplasms are of exophytic nature, difficulty is encountered in the diagnosis, assessment and quantification of invasion in small biopsies. Researchers herein investigated biopsy samples with excisional specimens in a cohort of patients diagnosed with papillary squamous cell carcinoma for the presence and extent of cervical stromal invasion. From the surgical pathology files between the years 2003 and 2018, they identified 18 cases, who underwent an excisional procedure following the diagnostic biopsy, for inclusion; their age ranged from 21 to 72 yr (mean: 46.2 yr). Analysis revealed the presence of only invasive cancer in excisional samples in the significant majority of cases. Accounting data gained in this study, proper management could be done and under-treatment could be avoided.