Lu L, et al. - The survival benefit of pancreaticoduodenectomy (PD) in elderly patients (age ≥75 years) with pancreatic ductal adenocarcinoma (PDAC) was determined. Survival analysis disaggregated by gender, tumor size, American Joint Committee on Cancer stage, and tumor differentiation demonstrated comparable DSS in younger and elderly patients. Findings thereby suggested that for DSS, advanced age is not an independent risk factor. In a subset of elderly PDAC patients, PD is justified but it should be performed in a high-volume center to minimize the risk of postoperative complications.