Konukiewitz B, et al. - The genetic profile of pancreatic ductal adenocarcinoma was determined by analyzing the large and small cell types using massive parallel sequencing applying a 409 gene panel on an ion torrent system. Neuroendocrine tumor G3 only shared singular mutations in 5 different genes with neuroendocrine carcinomas, with the inclusion of TP53, CDKN2A, ARID1A, LRP1B and APC. Additionally, a majority of KRAS-positive neuroendocrine carcinomas expressed MUC1 (4/5) and carcinoembryonic antigen (3/5) as markers of ductal differentiation. A genetic and phenotypic association was demonstrated between approximately one-half of the pancreatic neuroendocrine carcinomas with pancreatic ductal adenocarcinoma.