Gordon-Dseagu VL, et al. - Pancreatic cancer incidence trends were examined on the basis of demographics and histologic type. Findings revealed an increased incidence of pancreatic cancer but patterns differed by demographic group and histologic type. In the USA, many of the trends paralleled changing the prevalence of lifestyle risk factors like smoking, overweight and obesity, and diabetes, especially for pancreatic adenocarcinoma, and improved diagnosis methods during the past 40 years.

Methods

• For evaluating temporal trends and pancreatic cancer rates, data was gathered from the Surveillance, Epidemiology and End Results (SEER) registries from 1974 to 2013.

Results

• Between the 1970s and 1990s, pancreatic cancer incidence rates declined but increased from 1994 to 2013 among White males.
• Between 1992 and 2013, the annual percent change (APC) in incidence among non-Hispanic White and Hispanic males was 0.84% and 0.73%, respectively.
• Rates also increased among White non-Hispanic, Hispanic and Asian females (APC = 0.81%, 0.56%, and 1.23%, respectively) and even more rapidly among females aged 25-34 years (APC > 2.5%).
• Rates remained unchanged among Black males and females, but higher compared with the other racial/ethnic groups.
• The increases were greatest for non-secretory endocrine cancers ( > 6%), followed by ductal adenocarcinomas (~5%) and adenocarcinoma, NOS (~1.4%)-the largest histologic subgroup of pancreatic cancer, by histologic type.
• Rates were decreased for mucinous adenocarcinomas and poorly specified pancreatic cancer.
• During 2000-13, incidence rates were higher among males than females [MF incidence rate ratio (IRR) = 1.28].
• At all ages ≥ 35, the IRR was >1.00, however, rates among females were higher at younger ages (IRRs 15-24: 0.66, 25-34: 0.81).
• Among males, the MF IRRs for most of the histologic types were elevated apart from solid pseudopapillary adenocarcinoma and cystic carcinomas (IRR = 0.22, confidence interval: 0.14-0.34 and 0.52, 0.41-0.65, respectively).