Ghazizadeh-Hashemi M, et al. - The efficacy and tolerability of palmitoylethanolamide (PEA) add-on therapy were investigated in the treatment of patients with the major depressive disorder (MDD). Findings suggested the efficacy of palmitoylethanolamide adjunctive therapy to citalopram in improving symptoms of patients (predominantly male gender) with major depressive disorder. As per outcomes, treatment with PEA appeared to be well tolerated with no serious adverse event.