Scheller U, Lofredi R, van Wijk BCM, et al. - Researchers intended to determine if there is an association between pallidal low-frequency activity and motor sign severity in dystonia [defined as a movement disorder characterized by sustained or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both] after chronic deep brain stimulation for several months. Using Burke-Fahn-Marsden Dystonia Rating Scale, local field potentials were recorded in 9 dystonia patients at 5 timepoints (T1–T5) during an OFF-stimulation period of 5 to 7 hours in parallel with clinical evaluation. They used a linear mixed effects model to examine the potential connection of motor signs with local field potential activity in the low frequency (3–12 Hz) and beta range (13–30 Hz). According to results, a significant connection of Burke-Fahn-Marsden Dystonia Rating Scale scores with low-frequency activity, but not beta activity (13–30 Hz) was disclosed across time points among candidates. Dystonic motor sign severity is correlated with low-frequency activity, even months after chronic deep brain stimulation. The outcomes confirm the pathophysiological function of low-frequency activity in dystonia and highlight the potential usefulness of adaptive neuromodulation as a biomarker.