Wang Q, Han A, Chen L, et al. - A total of 90 gastric cancer (GC) samples and 90 adjacent noncancerous tissues were used to investigate the expression of Paip1 by the researchers in order to discover Paip1 expression levels and examine its underlying molecular mechanism in GC. Paip1 expression was noted to be upregulated in GC and was related to shorter overall survival. Knockdown of Paip1 restricted cell proliferation, migration and led to cell cycle arrest in GC cells, whereas its overexpression reversed these impacts. Another mechanistic study exhibited that Paip1 overexpression promoted epithelial-mesenchymal transition progression and regulated its targets expression. Thus, high expression of Paip1 was concluded to play an important role in the progression of GC and could be a eligible biomarker of poor prognosis as well as a therapeutic target.