Brunkert T, et al. - In this implementation science pilot study, researchers focused on the efficacy as well as the implementation of a multilevel pain management intervention in nursing homes (NHs) including a pain management guideline, care worker training, and pain champions. For this investigation, a quasi-experimental effectiveness-implementation (hybrid II) design was used. This study was run in Switzerland. Participants included 62 long-term older residents who consented and had pain at baseline, and all registered and licensed practical nurses (n = 61). NH residents experienced a significant improvement in average and worst pain intensity following the implementation of a multilevel pain management intervention. As far as implementation efforts were concerned, familiarity with the guideline was stated by nearly 76% of care workers; and 70.4% admitted that the guideline is practical and meets their views of good pain evaluation (75.9%) and treatment (79.7%). Possibly, a more comprehensive approach including other disciplines is required to effect clinical significant shifts in interference from pain.