Sodhi JK, et al. - Researchers assessed data from a prospective cohort study of 1,545 community-dwelling Mexican Americans aged ≥ 67 years from the Hispanic Established Populations for the Epidemiological Study of the Elderly (1995/1996-2012/2013) in order to investigate pain as a predictor of frailty over 18 years of follow-up among older Mexican Americans who were nonfrail at baseline. They defined frailty as meeting 2 or more of the following: unintentional weight loss of > 10 pounds, weakness, self-reported exhaustion, and slowness. Pain at baseline was reported in 538 participants (34.8%). The prevalence of frailty among those with pain ranged from 24.4% in wave 3 to 41% in wave 8. Findings suggest pain as a significant predictor of frailty. Higher odds of becoming frail over time were also observed in correlation to older age, hip fracture, high depressive symptoms, and activities of daily living disability. The risk was lower among female participants and those with higher levels of education and high Mini-Mental State Examination scores. Based on these findings they suggest the possible significance of undertaking early assessment and better management of pain for preventing early onset of frailty in older Mexican Americans.