Wan DWL, et al. - Researchers investigated the existence of dichotomy of pain adaptability in individuals with chronic musculoskeletal pain (MSK). Findings support that this dichotomy exists in individuals with chronic musculoskeletal pain and could be reliably assessed with cold pressor tests at 2°C and 7°C. Similar to the healthy human study, pain adaptability is not found to have an association with conditioned pain modulation and may reflect the temporal aspect of pain inhibition.