Peska E, Balki M, Maxwell C, et al. - By performing this double‐blind dose‐finding study using the biased coin up‐down design method, researchers intended to establish the bolus dose of oxytocin needed to start effective uterine contraction in 90% of women with obesity (the ED₉₀) at elective caesarean section. Participants were term pregnant women with a BMI ≥ 40 kg.m⁻² undergoing elective caesarean delivery under regional anaesthesia. Oxytocin was delivered as an intravenous bolus over 1 minute upon delivery of the fetus. Oxytocin doses were delivered as per a sequential allocation scheme, with the first woman receiving 0.5 IU. By isotonic regression and by the Dixon and Mood method, the ED₉₀ for oxytocin was 0.75 IU and 0.78 IU, respectively. According to the findings, oxytocin needed in women with a BMI ≥ 40 kg.m^‐2 was noted to be approximately twice to that required in women with a BMI < 40 kg.m^‐2 , in whom an ED₉₀ of 0.35 IU (95%CI 0.15–0.52 IU) has previously been shown.