Wan Y, Yuan J, Li J, et al. - Experts aspired to explore if the gut microbiota and intestinal energy metabolites differ in underweight, normal weight and overweight people, and their associations with host cardiometabolic risk factors. In 29 underweight, 67 normal weight, and 67 overweight healthy adults, gut microbiome, intestinal energy metabolites, circulating cardiometabolic risk factors and proinflammatory markers were determined. The intestinal concentration of tricarboxylic acid (TCA) cycle intermediate succinic acid was positively linked to body weight, and fumaric acid and malic acid were in a positive relationship with circulating total cholesterol, low-density lipoprotein cholesterol, and interleukin-1β. Findings suggested an association of low gut microbiota diversity with both overweight and underweight status. Intestinal TCA cycle intermediates were correlated with overweight development and could be potential markers for further studies related to gut microbiota and host cardiometabolic health.