Dai J, et al. - Through 77 cases pathologically confirmed primary ovarian cancer (OC) tissues and 25 cases of normal ovarian tissues obtained from patients undergoing ovarian resection, the researchers intended to evaluate the ability of MicroRNAs (miRs)-195-5p affecting cisplatin (DDP) resistance and angiogenesis. Lower expression of miR-195-5p while phosphoserine aminotransferase 1 (PSAT1) was higher, was noted in OC tissues than in adjacent normal tissues. Reduction in expression of HIF-1α, VEGF, PSAT1, β-catenin as well as the extent of GSK3β phosphorylation, the angiogenesis and resistance to DDP; and promotion of apoptosis both in vitro and in vivo, with over-expression of miR-195-5p or silenced PSAT1, providing a potential therapeutic target for the treatment of OC was concluded by the authors.