Yu Z, Wang Y, Hu X, et al. - In patients with chronic rhinosinusitis with nasal polyps (CRSwNP), researchers evaluated the possible role of hypoxia-inducible factor 1α (HIF-1α) in promoting neutrophilic inflammation. By using immunohistochemistry, qRT-PCR, and western blot, HIF-1α expression was examined in sinonasal tissues from CRSwNP patients and healthy controls. In addition, the stimulatory impacts of several cytokines (IFN-γ, IL-17A, IL-6, etc.) and reagents (dexamethasone (DEX), clarithromycin (CAM) and curcumin (CUM)) on HIF-1α expression in cultured normal nasal epithelial cells (NECs) were assessed. Also, the impacts of CAM and glucocorticoid on nasal symptoms and signs of uncontrolled neutrophilic CRSwNP patients were assessed. Findings suggested an association of HIF-1α with neutrophilic inflammation and glucocorticoid resistance in patients with CRSwNP.