Li Y, et al. - In this retrospective study of 136 papillary thyroid carcinomas (PTCs), experts explored if FOXQ1 (a member of the forkhead transcription factor family) is associated with poor prognosis in PTC. To examine the clinical and prognostic significance of FOXQ1 expression in PTC, Rank-sum test, Chi-square test, Kaplan–Meier survival analysis, univariate and multivariate Cox analyses were used. Findings suggested an association of FOXQ1-positive expression with shorter disease-free survival; median disease-free survival of FOXQ1-positive patients was 23 months vs 128 months for FOXQ1-negative patients. Multifocality, extrathyroidal extension, and positive expression of FOXQ1 were additional independent risk factors. To evaluate the progression of PTC and to forecast likely relapse of disease, FOXQ1 might be a valuable additional biomarker.