Peng J, et al. - Authors gauged the clinical significance of chloride channel-3 (CLC-3) and its biological role in gastric cancer. In gastric cancer tissues and cell lines, CLC-3 was highly expressed, there was a significant association of high levels of CLC-3 with adverse clinicopathological parameters and shorter overall survival time in patients with gastric cancer. Results demonstrated that in gastric cancer progression, CLC-3 had a vital role and it had a potential role of a therapeutic target for treatment. The proliferation, migration and invasion of gastric cancer cells in vitro was decreased with silencing of CLC-3 and promoted with overexpression.