Perrouin-Verbe MA, et al. - In this case-control study, selected proteins contributing to calcium (Ca²⁺) signaling, (Orai, stromal interaction molecule, and transient receptor potential (TRP) channels) and involved in cancer hallmarks, were investigated for their independent value as predictors of systemic recurrence after radical prostatectomy (RP). One hundred and twelve patients with clinically localized prostate cancer treated by RP between 2002 and 2009 and with at least 6-years’ follow-up were included. In this work, for the first time, certain proteins involved in Ca²⁺ influx were demonstrated to be the independent prognosticators of systemic recurrence after RP; researchers noted a lower risk of systemic recurrence in correlation with the overexpression of TRPC1, TRPC4, TRPV5, TRPV6, TRPM8, and Orai2. This study generates interest particularly in TRPC4, TRPV5, and TRPV6, as they are independent of the five commonly used predictive factors, that is, prostate-specific antigen, percentage of positive biopsies, surgical margin status, Gleason score, and pT stage.