Ye L, et al. - Given the aggressiveness of triple-negative breast cancer (TNBC) with high proliferative and metastatic phenotypes, and that CDCA7 (a new member of the cell division cycle associated family of genes) is involved in embryonic development and dysregulated in many types of human cancer, researchers examined the biological role and molecular mechanism of CDCA7 in TNBC. They noted that TNBC cell lines and tissues distinctly and preferentially express CDCA7. Patients with TNBC displaying high expression of CDCA7 were linked to metastatic relapse and were predicted to have a poorer disease-free survival. CDCA7 enhanced the expression of EZH2, which is an indicator of aggressive breast cancer involved in tumor progression, by increasing the transcriptional activity of its promoter. Findings thereby suggest that by transcriptionally upregulating EZH2, CDCA7 plays a crucial role in TNBC progression. CDCA7 could be a potential prognostic factor and therapeutic target in TNBC.