Wang X, et al. - In the pathogenesis of psoriasis, authors gauged the role of fibulin-3 (Fib3). Taken together, they noted an involvement of Fib3 in the pathogenesis of psoriasis by promoting angiogenesis. For treating psoriasis, Fib3 could serve as a potential target. Using a keratinocyte and endothelial cell coculture system, vascular endothelial growth factor (VEGF) expression in endothelial cells was upregulated with keratinocyte-derived Fib3. Endothelial cell proliferation and migration were induced by this treatment option.