Nguyen TYT, Cacciottola L, Camboni A, et al. - Given the documentation of ovarian metastasis potential in patients with leukaemia, borderline ovarian tumors, advanced breast cancer and Ewing sarcoma, researchers here investigated if there is a possibility of reseeding cancer cells potentially present in frozen ovarian tissue from patients with central nervous system (CNS) tumors. This is identified to be the first study performed in patients with CNS cancers undergoing ovarian tissue cryopreservation and transplantation. In the study, enrolled individuals were suffering from one of six types of CNS tumors including medulloblastoma, ependymoma, primitive neuroectodermal tumors, astrocytoma, glioblastoma and germinoma. Histology, immunohistochemistry (IHC), molecular biology or xenotransplantation did not detect malignancy reseeding in cryopreserved ovarian tissue from 20 patients with CNS tumors.