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Ovarian preservation in adenocarcinoma of the uterine cervix

Journal of Ovarian Research Aug 24, 2017

Zhou J, et al. – A retrospective study is carried out to identify the clinicopathological factors related to ovarian metastases (OM) in cervical adenocarcinoma (ADC). The outcome of this study suggests cervical ADC is related to an increased risk of OM. Ovarian preservation surgery in cervical ADC may be safe for young patients at an early Federation of Gynecology and Obstetrics (FIGO) stage without deep stromal, endometrial or perineural invasion, and especially without uterine corpus invasion, parametrial involvement and infiltration into the vagina.

Methods

  • Between Oct. 2006 and Sept. 2014, patients with International Federation of Gynecology and Obstetrics (FIGO) stage I–IIB cervical ADC who underwent the radical hysterectomy, including pelvic lymphadenectomy and bilateral salpingo–oophorectomy at their institution were enrolled in this study.
  • In this study, clinicopathologic factors were studied by univariate and multivariate examinations.

Results

  • In this study, total 312 patients were enrolled.
  • Out of these 312 patients, 14 patients (4.5%) developed OM.
  • Multivariate investigation uncovered that uterine corpus involvement (odds ratio [OR] 5.178, p = 0.019), parametrial involvement (OR 14.125, p = 0.005) and vaginal infiltration (OR 4.167, p = 0.047) were independently related to metastasis.
  • OM had no impact on either relapse–free survival (95% confidence interval [CI]: 0.077–4.095, p = 0.57) or overall survival (95% CI: 0.893–9.820, p = 0.076).

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