Ceppi L, et al. - Among 548 patients diagnosed with epithelial (EOC) or nonepithelial (no-EOC) invasive ovarian neoplasm during 1980 and 2014, researchers analyzed the impact of chemotherapy exposure (CE) on ovarian function in young women with ovarian neoplasms undergoing fertility-sparing treatment (FST). Investigators ascertained if CE was associated with during-treatment and post-treatment amenorrhea, conception rate, pregnancy outcome, and spontaneous menopausal age. According to findings, CE in no-EOC was correlated with an increased risk of during-treatment amenorrhea, post-treatment amenorrhea, and earlier spontaneous menopausal age. In EOC patients, there was no association between CE and decreased fertility. Patients undergoing FST had encouragingly high rates of conception and low rates of premature ovarian failure. However, the risks of this approach in such young population should be discussed in pretreatment counseling.