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Ovarian function, fertility, and menopause occurrence after fertility-sparing surgery and chemotherapy for ovarian neoplasms

Gynecologic Oncology Dec 25, 2018

Ceppi L, et al. - Authors studied 548 cases in this study to evaluate the correlation between chemotherapy exposure (CE) and the outcomes in young females with ovarian neoplasms (ie, during treatment and post-treatment amenorrhea, conception rate, pregnancy outcome, and spontaneous menopausal age). They observed the subjects undergoing fertility-sparing treatment (FST) had high conception rates and low premature ovarian failure rates. No link was noted between increased risk of during-treatment amenorrhea, post-treatment amenorrhea, and earlier spontaneous menopausal age and CE in epithelial (EOC) invasive ovarian cancer but was reported correlated with CE in nonepithelial (no-EOC) invasive ovarian neoplasm.
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