Alcobendas R, et al. - Given that the traditional approach for acute paediatric osteoarticular infections (OAI) has comprised initial intravenous antibiotics followed by prompt oral antibiotics, the researchers evaluated how providing just oral antibiotics compared to the traditional two-step approach. From September 2015 to September 2016, this prospective study was performed at the Hospital La Paz, Madrid, Spain. For this analysis, they compared 25 outpatients, with good general health and a mean age of 25 months who received just oral antibiotics, with two hundred twenty-eight hospitalised children of a similar age who received intravenous and oral antibiotics from other hospitals in the Spanish Network of Osteoarticular Infections. The findings demonstrated that outpatients with OAI who were in good general health had favourable outcomes when they took oral antibiotics without intravenous antibiotics.