Gaba P, Serruys PW, Karmpaliotis D, et al. - Researchers investigated the results of outpatient percutaneous coronary intervention (PCI) in patients with unprotected left main coronary artery disease (CAD) (LMCAD). Randomization to PCI with everolimus-eluting stents vs coronary artery bypass grafting was done on 1,905 patients with LMCAD and site-assessed low or intermediate SYNTAX scores, in the EXCEL trial. Major adverse cardiovascular events (MACE; the composite of death, stroke, or MI) were assessed as the primary endpoint. Less probability of having encountered recent MI was observed in patients who underwent outpatient vs inpatient PCI. Similarity in terms of distal LM bifurcation disease involvement and SYNTAX scores was evident between the groups. Overall, findings revealed that outpatient PCI of patients with LMCAD was not related to an excess early or late hazard of MACE in the EXCEL trial. Thus, outpatient PCI may be safely conducted in select patients experiencing LMCAD.