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Outdoor pollen‐related changes in lung function and markers of airway inflammation: A systematic review and meta‐analysis

Clinical & Experimental Allergy Feb 08, 2021

Idrose NS, Walters EH, Zhang J, et al. - To qualitatively as well as quantitatively synthesise the evidence of outdoor pollen exposure on several lung function as well as airway inflammation markers in community‐based investigations, this study was conducted. Medline, Web of Science, CINAHL and Google Scholar databases were explored to identify human‐based researches published in English that were representative of the community. In addition, only cross‐sectional or short‐term longitudinal investigations which explored pollen exposure by levels or season were considered. A total of 6,551 studies were identified, of those, 27 were included. Findings revealed that type‐2 upper and lower airway inflammation was triggered, instead of a non‐specific or innate inflammation, as a result of exposure to increased ambient pollen in individuals with ever asthma and ever seasonal allergic rhinitis. These observations can result in formulation of specific pollen immunotherapy for susceptible people.

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