Spiceland CM, et al. - Experts sought to evaluate outcomes in a diverse cohort of patients with Clostridium difficile infection (CDI) treated with fidaxomicin. No recurrence was observed in all patients with a first CDI episode who were treated with fidaxomicin. Results revealed that patients with prior CDI episodes were less likely to respond (especially with more than 1 prior episode) and more likely to recur. This finding suggested a greater clinical benefit of using fidaxomicin earlier in the course of CDI.