Sarma AA, Braunwald E, Cannon CP, et al. - Across trials performed by the Thrombolysis In Myocardial Infarction (TIMI) Study Group, researchers performed a sex-specific analysis of cardiovascular results post-NSTEACS (non–ST-segment elevation acute coronary syndromes) to determine the impact of sex on cardiovascular outcomes in this dataset. They identified 10 TIMI trials with > 2,500 patients with NSTEACS within 30 days of hospitalization. The association of sex with major adverse cardiovascular events (MACE) was determined using Cox proportional hazards models, after adjusting for relevant risk factors in individual trials. There were 68,730 patients with NSTEACS, including 19,827 (29%) women. Findings revealed a lower risk of MACE in women vs men post-NSTEACS, after accounting for cardiovascular risk factors. Undertreatment with many evidence-based therapies was reported for women.