Ghadersohi S, et al. - The target of this trial was to estimate the risk factors for persistent perforation and outcomes of tympanoplasty in Down syndrome (DS) patients. The data shed light on the connection between persistent tympanic membrane (TM) perforation in the study cohort with a history of chronic otitis media with effusion (COME)/Eustachian tube dysfunction (ETD), and multiple prior TT insertions. It was determined that tympanoplasty was successful for repair in a majority of the individuals who underwent surgical intervention. However, residual hearing loss appeared to be common.