Sarraj A, et al. - In this secondary analysis of a randomized clinical trial, authors analyzed if the imaging-based selection criteria employed in the endovascular therapy following imaging evaluation for ischemic stroke 3 (DEFUSE 3) trial would lead to comparable outcome rates and treatment gains in transfer vs direct-admission patients. They noted transfer subjects with longer median times from last known well to study site arrival (9.43 vs 9 hours) and more favorable collateral profiles (based on hypoperfusion intensity ratio): median for transfer, 0.35 vs 0.42 for direct. They did not find any variation in the primary outcome (90-day modified Rankin Scale score shift) in the direct vs transfer groups. No difference was observed in thrombectomy reperfusion rates, mortality, and symptomatic intracranial hemorrhage rates.