Auger N, et al. – Researchers conducted a matched cohort study involving 174 individuals with takotsubo syndrome between 1989 and 2006 in Quebec, Canada, to evaluate the long-term risk of morbidity and mortality in individuals with takotsubo syndrome. During 15 years of follow-up, individuals with takotsubo syndrome had a comparable risk of in-hospital mortality as individuals with myocardial infarction, but with a lower risk of cardiovascular rehospitalization. In contrast with population controls, takotsubo was associated with 1.59 times, 2.71 times, and 1.86 times the risk of in-hospital mortality, the risk of cardiovascular rehospitalization, and the risk of hospitalization for stress and anxiety disorders, respectively. Relationships were significantly more robust the first few years following the initial admission for takotsubo, and diminished over time. Thus, takotsubo syndrome is related to a comparable risk of mortality as myocardial infarction following 15 years, although with a lower risk of cardiovascular rehospitalization. Individuals with takotsubo syndrome, compared with population controls, nevertheless, have greater in-hospital mortality and cardiovascular morbidity.