Kamrava M, et al. - Researchers studied breast cancer patients who were treated with breast-conserving therapy using adjuvant accelerated partial breast irradiation (APBI) with interstitial multicatheter brachytherapy and had >1 year of data available and nodal status information. The goal was to compare the outcomes of node-positive vs node-negative patients. The observed 5-year actuarial local control (95% confidence interval) in node-negative vs node-positive patients was 96.3% vs 95.8% and observed 5-year actuarial regional control was 98.5% vs 96.7%. A higher risk of local/regional recurrence was found to be related to age 50 years and below, Her2 positive, positive margin status, and not receiving chemotherapy or antiestrogen therapy in multivariate analysis. Overall, patients who have had an axillary lymph node dissection and limited node-positive disease may be candidates for treatment with APBI.