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Outcomes of monochorionic twin pregnancies complicated by type‐III selective fetal growth restriction

Ultrasound in Obstetrics & Gynecology Oct 24, 2020

Shinar S, Xing W, Pruthi V, et al. - Given the association of type III selective intrauterine growth restriction (sIUGR) with a high and unpredictable risk of fetal death and fetal brain injury, researchers sought to delineate the prospective risk of fetal death and the risk of adverse neonatal outcomes in a contemporary cohort. They retrospectively reviewed data on 328 monochorionic diamniotic twin pregnancies (656 fetuses) complicated by type III sIUGR managed at nine fetal centers over a 12‐year time period. Following exclusion of pregnancies which underwent selective reduction (n = 18, 5.5%), 51 (8.3%) non‐iatrogenic fetal deaths were identified in 35 pregnancies (11.3%). In 19 (5.8%) pregnancies and 16 (4.9%) pregnancies, single deaths and double deaths occurred, respectively. They observed decline in the prospective risk of non‐iatrogenic fetal death per fetus from 8.1% at 16 weeks, to less than 2% after 28.4 weeks and to less than 1% beyond 32.6 weeks. In otherwise uncomplicated type III sIUGR, generally planned delivery was conducted at 32 weeks, at which time the risk of composite adverse neonatal outcomes was 29% (31/107 neonates). Relative to previous reports, findings suggested a lower risk of fetal death in type III sIUGR.

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