Hu SY, Rezhake R, Chen F, et al. - Researchers estimated long-term results of biopsy-verified cervical intraepithelial neoplasia grade 1 (CIN1) or normal cervix, as well as explored the cofactors during disease progression. A total of 1,997 women aged 35–45 were enrolled in a cervical cancer screening cohort in Shanxi, China, in 1999. These individuals were observed at year 6, 11, and 15 post-enrollment. Among CIN1, the cumulative rates of progression to CIN2+ were estimated to be 7.5%, 21.4%, and 24.0% over 6, 11, and 15 years, respectively; and the regression rates to normal cervix were reported to be 85.0%, 76.7%, and 72.9%, respectively. Significantly higher progression rates to CIN2+ were reported for CIN1 or normal cervix positive for high-risk human papillomavirus (hrHPV) vs those without hrHPV. Considering these findings, it was inferred that based on hrHPV/cytology status, clinical follow-up strategies for females having CIN1 or normal cervix could be adjusted accordingly.