Jones E, et al. - The purpose of this study was to identify the burden of long-term sequelae and death following severe hand, foot and mouth disease (HFMD). Data came from English and Chinese databases, including MEDLINE and Wangfang, on outbreaks of clinically diagnosed HFMD and/or laboratory-confirmed EV-A71 with a minimum 7 days’ follow-up published between 1st January 1966 and 19th October 2015. Researchers calculated 19.8% as the cumulative incidence of death or neurological sequelae at maximum follow up. There is a significant burden of long-term neurological sequelae in HFMD with neurological involvement, with grade of acute disease severity appearing to be a strong predictor of outcome.