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Outcomes associated with clopidogrel-aspirin use in minor stroke or transient ischemic attack: A pooled analysis of Clopidogrel in High-Risk Patients With Acute Non-Disabling Cerebrovascular Events (CHANCE) and Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trials

JAMA Neurology Aug 26, 2019

Pan Y, Elm JJ, Li H, et al. - For minor ischemic stroke or transient ischemic attack, researchers assessed the ideal length of dual antiplatelet therapy. From two large-scale randomized clinical trials that evaluated clopidogrel-aspirin as a treatment to prevent stroke after a minor stroke or high-risk transient ischemic attack (TIA), they gathered the data for this study. They noted a decrease in the risk of major ischemic events with no increase in the risk of major hemorrhage when patients with minor stroke or transient ischemic attack were treated with early and short-term clopidogrel-aspirin treatment. Findings thereby emphasize initiating dual antiplatelet therapy as soon as possible in patients with acute minor stroke or transient ischemic attack, but ideally within 24 hours after symptom onset, and continuing it for a period of 21 days.

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