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Outcomes and risk factors of massive and submassive pulmonary embolism in children: A retrospective cohort study

The Lancet Haematology Feb 20, 2019

Pelland-Marcotte MC, et al. - Researchers undertook this retrospective cohort study including consecutive patients aged 18 years or younger with acute pulmonary embolism to describe pulmonary embolism outcomes in children. Further, they sought risk factors for unfavourable outcomes and evaluated the discriminative ability of two clinical-severity indices in these cases. From two Canadian paediatric hospitals (The Hospital for Sick Children, Toronto, ON, and the Children's Hospital of Eastern Ontario, Ottawa, ON), they included 170 patients, 37 (22%) with massive, 12 (7%) with submassive, and 121 (71%) with non-massive pulmonary embolism. Observations revealed higher rates of unfavourable outcomes in correlation with massive or submassive pulmonary embolism than non-massive pulmonary embolism in children. To predict 30-day mortality, the area under the receiver-operating characteristic (ROC) curve for pulmonary embolism severity index (PESI) was 0·76 (95% CI 0·64–0·87). Simplified PESI (sPESI) had sensitivity of 100% and specificity of 30%.
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