Geller S, Lebowitz E, Pulitzer MP, et al. - In African American (AA)/black patients with mycosis fungoides/Sézary syndrome (MF/SS), researchers described the outcomes and identified prognostic factors. They analyzed clinical characteristics and follow-up data in 157 self-identified AA/black patients seen between 1994-2018. One hundred twenty-two patients with early-stage MF and 35 patients with advanced-stage disease were included. Hypopigmentation patients had better overall survival and progression-free survival, either as the sole manifestation or in combination with other lesions. Outcomes were also significantly associated with clinical stage, TNMB classification, plaque disease, and elevated serum lactate dehydrogenase. In AA/black patients, MF/SS manifestations and outcomes are heterogenous. Demographic and socioeconomic factors do not appear to have a prognostic function, while clinical features may assist in stratify the danger of progression and shorter survival, enabling individual therapeutic interventions.