Cho MS, et al. - Researchers determined the effect of pre-discharge initiation of beta-blocker (BB) treatment on clinical outcomes in patients enrolled in the Korean Acute Heart Failure (KorAHF) registry. The risk of post-discharge mortality and re-hospitalization was compared between groups with and without pre-discharge BB treatment among BB-naive patients suffering from heart failure with reduced ejection fraction (median 67.0 years, 62.5% male, median LVEF 24.1%). Pre-discharge BB groups had consistently lower all-cause mortality in Cox’s proportional hazards model after multivariable adjustment and adjustment for propensity score methods using the inverse probability of treatment weighting. Overall, pre-discharge BB initiation was found to be related to better clinical outcomes after severe acute decompensated heart failure episodes requiring inotropic therapy.