Jones DA, et al. - In a large contemporary cohort of successive patients, researchers assessed the frequency and outcomes of chronic total occlusions (CTO)-percutaneous coronary intervention (PCI) procedures. They analyzed 48,234 patients with stable angina, of which 5,496 (11.4%) procedures were performed for CTOs between 2005 and 2015 at 9 tertiary cardiac centers across London, United Kingdom. There was a median follow-up of 4.8 years (interquartile range: 2.2–6.4 years) during which outcome was assessed by in-hospital major adverse cardiac events and all-cause mortality. Findings revealed lower mortality in relation to successful procedures, suggesting that clinical outcomes could be improved in a wider population than are currently being offered therapy by ensuring greater uptake of CTO PCI.