Ramdath A, Zeineddin A, Nizam W, et al. - The characteristics and outcomes of cholecystectomy were examined in cases with  sickle cell disease (SCD) vs without SCD. In addition, they determined the role of acuity of presentation. From the Nationwide Inpatient Sample (2005-2014), they identified 149,415 patients with the primary diagnosis of gallbladder disease who were less than age 35 and underwent cholecystectomy. Treatment groups were formed by sickle cell status and acuity of surgery. Analysis indicated association of SCD with a longer length of stay, higher hospital spending and increased complication rates when compared with non SCD patients undergoing cholecystectomy. Patients undergoing surgery in the acute setting exhibited this difference pronouncedly. Per data gained, planned cholecystectomy may benefit SCD patients via improving their postoperative outcomes.