Ahmed N, Owen J, Abdalmassih M, et al. - Via performing this institutional review, researchers sought to report on the outcome of patients with locally advanced esophageal cancer (LAEC) treated with neoadjuvant chemoradiation (C-RT) or perioperative chemotherapy (P-CT) followed by surgery. From the Manitoba Cancer Registry, they identified 67 patients treated with C-RT and 32 with P-CT. Outcomes suggest a higher degree of pathologically tumor regression in correlation with C-RT. A better outcome was reported for patients with major tumor regression vs those with minimal to poor response. Although C-RT was associated with a trend toward improved time to recurrence, there was no difference in overall survival or recurrence-free survival.