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Outcome of early-stage glottic laryngeal carcinoma patients treated with radical radiotherapy using different techniques

Journal of Oncology Nov 20, 2019

Cetinayak O, Dogan E, Kuru A, et al. - In the present study, the researchers assessed the treatment results and prognostic features of patients with early-stage glottic laryngeal carcinoma who had radical radiotherapy (RT) with different techniques. They applied radiotherapy utilizing the 2D conventional technique between 1991 and 2004 (130 individuals), 3DCRT until 2014 (125 patients), and by VMAT until January 2017 (44 patients). According to results, the median total dose was 66 (50–70) Gy, and median follow-up time was 72 (3–288) months; 5-year disease-specific survival (DSS) rates were 95.8%, 95.5%, and 88.6%, respectively, in Tis, T1, and T2 stages. Anterior commissure involvement was found significant for all survival and local control rates in multivariate analyses. The VMAT-treated patients had better local control and DSS rates. Such outcomes, however, were not statistically significant. Findings suggested that radical RT is a function sparing and effective treatment modality in early-stage laryngeal carcinomas, independent of treatment techniques.
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