Schaub F, et al. - This retrospective, comparative, interventional case series was undertaken to determine if corneas from donors ≥ 80 years old were suitable for Descemet membrane endothelial keratoplasty (DMEK). The authors reviewed and matched records of 1,765 consecutive DMEKs with corresponding donor tissue data. They compared older donors (≥ 80 years of age) to younger donors (< 80 years). Of 1,748 DMEKs, 284 were conducted with older donor lamellae (mean donor age, 83.96 ± 3.19 years) and 1,464 (83.7%) with younger donor tissue (mean donor age, 65.27 ± 9.57 years). For all postoperative time points, BSCVA outcomes were comparable. The endothelial cell density values were significantly higher in preoperative donors < 80 years of age and in the first 2 years postoperatively. According to results, older donors, ≥ 80 to 94 years of age, appear to produce similar mid-term functional outcomes following DMEK surgery vs younger donors. Therefore, the use of corneas for DMEK surgery from donors aged ≥ 80 may be a promising approach to counteracting global donor shortages.