El Shafie RA, et al. - In selected patients with leptomeningeal carcinomatosis (LC), researchers reported their 10-year experience with palliative craniospinal irradiation (CSI). Based on clinical performance, presenting symptoms and estimated benefit, 25 patients were selected to get of CSI for the treatment of LC. At the time of analysis, 21 patients died and 4 were alive. A median overall survival (OS) from LC diagnosis of 19.3 weeks was noted. A Karnofsky performance scale index (KPI) ≥70%, age ≤55 years at LC diagnosis, and only mild or moderate neurologic deficits were predictive of longer OS. These findings suggest feasibility and a possible therapeutic value of CSI for the treatment of LC in carefully selected patients in easing symptoms or postponing neurologic deterioration. This study yielded a comparable OS outcome after CSI to that described in current literature for patients with LC. They support the use of modern irradiation techniques such as helical intensity-modulated radiotherapy to limit toxicity.