Sun TT, et al. - In this systematic review, researchers assessed the diagnostic performance of osteopontin (OPN) for hepatocellular carcinoma (HCC). Searching PubMed and Embase Studies, they included 12 studies in this meta-analysis. Outcomes revealed pooled sensitivity of serum OPN, alpha-fetoprotein (AFP), and OPN+AFP for diagnosis of early HCC of 0.493, 0.517, and 0.732, respectively. Hence for the diagnosis of HCC, OPN is a comparable marker to AFP, with higher sensitivity. Combining AFP and OPN may improve the sensitivity of diagnosis for early HCC.